Sr. Scientist / Principle Scientist / Associate Director, Immune Oncology

Status: 
Full Time
Location: 
Boston, MA

Description:

We are seeking a highly motivated and experienced immune-oncologist to join our antibody engineering and function analysis team for therapeutic antibody candidate development to utilize immunological principles to eradicate cancer. The position requires in-depth knowledge in the immuno-Oncology field. The qualified candidate should have hands on experience in establishing in vitro assays that interrogate immune system, skills in evaluating the effect of drug candidate on the immune end points and biomarkers and knowledge of principles of antibody characterization and engineering. S/he also has project leadership with strong collaborative and communication skills, proactive attitude and critical problem-solving abilities and an awareness of current trends and technologies.

Responsibilities:

  • Develop and optimize cell based functional assays (immunology assays using primary cells, tumor cell lined and function reporter cell system), for antibody in vitro functional characterization (e.g. signaling inhibition/activation, proliferation, cytotoxicity)
  • Conduct and guide junior scientists in multi-color/multi-parameter high throughput flow cytometry experiments and data analysis
  • Serve as a biotherapeutic leader on projects in a cross-functional team setting and act as a champion for the Antibody Engineering and Function Characterization group
  • Act as a liaison and forge collaborative relationships with other research units and contribute to target validation for biotherapeutic development
  • Contribute to authorship of technical reports for patent applications and scientific publications
  • Take active role in coaching and mentoring the junior team members.

Qualifications:

  • PhD in immunology, molecular biology, or related life sciences
  • At least 5-10 years’ industry experience or equivalent in academia
  • Expertise in immune-checkpoint modulation, T cell and other immune cell biology with knowledge of various therapeutics modalities
  • Technical expertise in establishment and validation of cell surface receptor binding assays, internalization by FACS, ELISA and other cell based assays
  • Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by the publication in peer-reviewed journals, or successful experiences in Bio-pharm industry
  • Demonstrated experiences in antibody based biotherapeutics characterizing and testing from discovery to lead optimization
  • Strong interpersonal and management skills,
  • Excellent communication and organizational skills,
  • Self-motivated and adept at regularly delivering towards deadlines, and strong skills in troubleshooting
  • Take initiative readily and further develop expertise as needed; stay current on relevant literature
  • Enthusiastic about communicating to a broad range of stakeholders (from novices to experts)
  • Curiosity about seeking and applying current relevant scientific literature toward new solutions

Job Type: Full-time

Required education:

  • Doctorate

Required experience:

immunology: 5 years

 

 

We offer competitive compensation package, for additional information, please contact: info@qlb-bio.com